Saturday, April 02, 2011

Gleevec for CLL

Mcl-1 is one of those anti-apoptotic proteins that belong to the bcl-2 family. It may well be the most important in CLL. A paper from Liverpool has demonstrated that c-Abl is involved in the up-regulation of Mcl-1 in CLL which suggests that Imatinib (Gleevec) might have a role in its management.


Burke said...


How long would you guess it will be before Gleevec is available for use by cll patients, if at all

Terry Hamblin said...

I doubt that it will be. There are other TK inhibitors in front of it.

Tom said...

Dr. Hamblin. Are you refering to PCI 32765 and Cal 101 or is something even better pehaps being looked at.
God Bless.

Terry Hamblin said...

Both of these with others in the pipeline.

H said...

Merci pour votre blog je lis l'année 2006
Now in my poor English; thanks for the information you provide on this blog. Having a CCL stade A I am interested by the articles you wrote on the subject. At this time I am travelling across year 2006.
best wish for your health.
Bonne santée