Friday, April 01, 2011
Prognostic markers again.
A new paper from Montserrat's group on prognostic markers in stage A CLL suggests that the most useful indicators of a short progression-free survival are a total white count of greater than 30k and unmutated IGHV genes. The problem with the FISH abnormalities del 17p and del 11q is that they are so rare in stage A cases that they really do not really make an impact, whereas unmutated IGHV genes occur in 36% of cases. In multivariate analysis CD38 and ZAP-70 were squeezed out. Perhaps after 12 years people will begin to realize that V gene mutations ought to be done in every case.