Saturday, April 02, 2011

Gleevec for CLL

Mcl-1 is one of those anti-apoptotic proteins that belong to the bcl-2 family. It may well be the most important in CLL. A paper from Liverpool has demonstrated that c-Abl is involved in the up-regulation of Mcl-1 in CLL which suggests that Imatinib (Gleevec) might have a role in its management.
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5 comments:

  1. Burke02 April, 2011 19:41

    Doc,

    How long would you guess it will be before Gleevec is available for use by cll patients, if at all

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  2. Terry Hamblin03 April, 2011 11:44

    I doubt that it will be. There are other TK inhibitors in front of it.

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  3. Tom04 April, 2011 08:36

    Dr. Hamblin. Are you refering to PCI 32765 and Cal 101 or is something even better pehaps being looked at.
    God Bless.

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  4. Terry Hamblin04 April, 2011 09:01

    Both of these with others in the pipeline.

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  5. profile blogger de RV montel04 April, 2011 21:40

    Bonjour
    Merci pour votre blog je lis l'année 2006
    Now in my poor English; thanks for the information you provide on this blog. Having a CCL stade A I am interested by the articles you wrote on the subject. At this time I am travelling across year 2006.
    best wish for your health.
    Bonne santée
    regards
    Herve

    ReplyDelete