tag:blogger.com,1999:blog-19490962.post8728154126153031298..comments2023-12-10T10:06:41.979+00:00Comments on mutations of mortality: Lyn and Syk activate resistance pathwaysTerry Hamblinhttp://www.blogger.com/profile/06346629921055055879noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-19490962.post-11260698452341103152011-07-24T06:23:00.820+01:002011-07-24T06:23:00.820+01:00Can't generalize yet.Can't generalize yet.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-41737104996501190112011-07-24T04:29:14.791+01:002011-07-24T04:29:14.791+01:00Dr. Hamblin,
So it is unlikely that just one inhi...Dr. Hamblin,<br /><br />So it is unlikely that just one inhibitor will worlk on CLL? Do you expect that multiple drugs would be needed simultaneously to block all of the signaling pathways?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-60457509949759510362011-07-23T23:04:36.622+01:002011-07-23T23:04:36.622+01:00Possibly.It is an interesting thought.Possibly.It is an interesting thought.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-65157741288267820652011-07-23T19:39:06.102+01:002011-07-23T19:39:06.102+01:00Terry,
You said:
Activation of the transcription...Terry,<br /><br />You said:<br /><br />Activation of the transcription factor NFAT by calcineurin-mediated dephosphorylation results in transcription of several genes including those of IL-2, IL-4 and gamma-interferon, which block apoptosis of CLL cells.<br /><br />Does that perhaps explain the significant anti-leukemic effects I have enjoyed from taking cyclosporin a calcineurin inhibitor for my ITP?<br /><br />Thanks for explaining all this difficult cell biology.<br /><br />Be well<br /><br />BrianBrian Koffmanhttps://www.blogger.com/profile/13250684684103918493noreply@blogger.com