tag:blogger.com,1999:blog-19490962.post8181637735487763354..comments2023-12-10T10:06:41.979+00:00Comments on mutations of mortality: How BiTE antibodies workTerry Hamblinhttp://www.blogger.com/profile/06346629921055055879noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-19490962.post-65522069874867849642011-06-25T23:03:55.235+01:002011-06-25T23:03:55.235+01:00The specificty comes from the choice of the target...The specificty comes from the choice of the target antigen. CD19 is fairly specific to B cells and apart from the encephalopathy risk side effects seems to be caused by the relase of cytokines in those with circulating tumor cells.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-63413943240613794592011-06-25T22:07:47.679+01:002011-06-25T22:07:47.679+01:00Given the that this is not a tumor cell specific t...Given the that this is not a tumor cell specific therapeutic, do you have any opinion on effectiveness vs risk that we can expect as this comes into use?<br /><br />WWWWaynehttps://www.blogger.com/profile/12333087913528941756noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-82265183060651117702011-06-25T14:24:39.103+01:002011-06-25T14:24:39.103+01:00I read somewhere a while back that this should wor...I read somewhere a while back that this should work especially well on marrow because the small rod shape could get into it better than the larger Y shaped antibodies.Burkenoreply@blogger.com