tag:blogger.com,1999:blog-19490962.post7649843368470769790..comments2023-12-10T10:06:41.979+00:00Comments on mutations of mortality: The role of CD38 in affecting CLL migrationTerry Hamblinhttp://www.blogger.com/profile/06346629921055055879noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-19490962.post-79311929513249273112011-10-18T12:30:25.053+01:002011-10-18T12:30:25.053+01:00I can't remember the biochemistry, but I have ...I can't remember the biochemistry, but I have written on it before and you will find a lot if you Google green tea. There was a Mayo Clinic Trial which established that it does have an effect, but it is not an effect worth spending all that money on.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-78063484694875818282011-10-18T12:03:41.621+01:002011-10-18T12:03:41.621+01:00Thank you for taking the time to respond just thro...Thank you for taking the time to respond just through nurse training so only know the basic of physiology and anatomy , let alone chemistry but how is it able to lower the white blood count and reduce nodes EGCG compound some how destroy some of the mutant B cells ? <br />I really do appreciate your time and yes sorry this is on a very basic level <br />StewStew (WORCESTER) UKnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-91898202804615672922011-10-18T10:59:27.578+01:002011-10-18T10:59:27.578+01:00EGCG undoubtedly has a minor therapeutic effect in...EGCG undoubtedly has a minor therapeutic effect in shrinking nodes and lowering white counts, but this is generally in patients who are on watch and wait who do not require treatment under international guidelines.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-33317224814032785912011-10-18T10:36:51.646+01:002011-10-18T10:36:51.646+01:00Good morning Terry , i hope you are feeling better...Good morning Terry , i hope you are feeling better just wanted to know your views on green tea extracts (1000mg daily) (EGCG) my close been taking the capsules for six weeks and nodes in his neck has virtually disappeared , he is currently on the watch and wait while this may be just a coincidence what are your thoughts on EGCG ? Due to have more blood tests shortly (FBC)Stew (WORCESTER) UKnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-73448834484095655042011-10-17T22:46:56.742+01:002011-10-17T22:46:56.742+01:00Discordant cases have an intermediate prognosis.Discordant cases have an intermediate prognosis.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-68302086283578178372011-10-17T20:29:04.905+01:002011-10-17T20:29:04.905+01:00ok, if discordant, does CD38- somehow help the unm...ok, if discordant, does CD38- somehow help the unmutated case?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-77344760624686049402011-10-17T18:03:23.948+01:002011-10-17T18:03:23.948+01:00ZAP-70 is unreliable. CD38 is discordant with IGHV...ZAP-70 is unreliable. CD38 is discordant with IGHV mutations in a third of cases.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-28456451132334859292011-10-17T18:00:31.118+01:002011-10-17T18:00:31.118+01:0033% are mutated and CD38 negative. 33% are unmutat...33% are mutated and CD38 negative. 33% are unmutated and CD38 positive and 33% are discordant.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-66947246498494224382011-10-17T16:11:39.014+01:002011-10-17T16:11:39.014+01:00Dear Dr.Hamblin,
My CLL type is unmutated with bot...Dear Dr.Hamblin,<br />My CLL type is unmutated with both CD38 and ZAP-70 negative. Why do these discrepancies happen in the markers (are they frequent?) and does any of them override the others (I mean mutational status versus CD38 and ZAP-70). Should we look at just the mutational status? <br />Thank you!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-47486847640015053602011-10-17T15:53:27.308+01:002011-10-17T15:53:27.308+01:00How do mutated or unmutated immunoglobulin variabl...How do mutated or unmutated immunoglobulin variable region heavy chain (IgVH) genes relate, if at all, to CD 38? <br /><br />Good to see you back at the computer! Go for a walk today!Anonymousnoreply@blogger.com