tag:blogger.com,1999:blog-19490962.post6920805137909799505..comments2023-12-10T10:06:41.979+00:00Comments on mutations of mortality: MBL v CLLTerry Hamblinhttp://www.blogger.com/profile/06346629921055055879noreply@blogger.comBlogger15125tag:blogger.com,1999:blog-19490962.post-82912215426649764332011-07-15T18:51:16.768+01:002011-07-15T18:51:16.768+01:00I am OK with it.I am OK with it.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-24264302018104248202011-07-15T18:47:48.566+01:002011-07-15T18:47:48.566+01:00Terry, I know I might be annoying you. Last one I ...Terry, I know I might be annoying you. Last one I promise. A<br />As I am not a native English speaker (sorry, I am so ashamed to ask you this), so has your "REALLY" meant that you are OK if I do not get tested again by RT-PCR?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-32413566286621471442011-07-15T17:37:35.837+01:002011-07-15T17:37:35.837+01:00REALLY.REALLY.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-36840628438010474462011-07-15T14:52:41.968+01:002011-07-15T14:52:41.968+01:00Terry, so I REALLY want to tell you this is the la...Terry, so I REALLY want to tell you this is the last one. You help me a lot. Again, out of sympathy...<br />Are you really ok with my option of putting it out and NOT going for another RT-PCR and live my life?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-14034822249417257002011-07-15T14:04:03.416+01:002011-07-15T14:04:03.416+01:00I suspect that MBL with CLL markers would be safe,...I suspect that MBL with CLL markers would be safe, but how far into early CLL remains safe is an open question that no-one has investigated.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-15003264778850385102011-07-15T13:51:02.950+01:002011-07-15T13:51:02.950+01:00Terry, thank you. I also believe I am not infected...Terry, thank you. I also believe I am not infected. Deep inside I know it after so many tests.<br />Just a theorical thought: talking about EARLY CLL patients (it´s not my case I know) who have not needed any treatment...would you only order standard serologies (the one that looks for antibodies only)instead of RT-PCR in case they've had some kind of contact of HIV, Hepatitis C, B, etc? I know they may not respond to vaccines but regarding "live viruses", wouldn't they respond differently?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-49381961930078586502011-07-15T08:43:37.116+01:002011-07-15T08:43:37.116+01:00No you would not be negligent. I am convinced that...No you would not be negligent. I am convinced that you are HIV negative.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-75480564911890027762011-07-15T02:01:19.280+01:002011-07-15T02:01:19.280+01:00Terry, I promise this wil be my last post...in you...Terry, I promise this wil be my last post...in your opinion, in case I try my best to put it out of mind, do you think I will be negligent with myself if I do not go for another PCR? I really donot want to take another test. I want to put it all this to an end.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-14429252499720236842011-07-14T23:09:31.154+01:002011-07-14T23:09:31.154+01:00I would only have another test if you can't pu...I would only have another test if you can't put this out of your mind.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-19300134979202814652011-07-14T21:10:48.811+01:002011-07-14T21:10:48.811+01:00Terry, thank you!
About the HIV issue, I would lik...Terry, thank you!<br />About the HIV issue, I would like to put it out of my mind. Did you mention to go for another RT-PCR just for "psychological" reasons or do you think it is clinically necessary after all the testing I have gone through?<br />I will follow your advice. To hear from a specialist (instead of going for another RT-PCR) would be ok for me.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-65650414416850061692011-07-14T20:47:31.169+01:002011-07-14T20:47:31.169+01:00Even with MBL you would certainly make anti-HIV an...Even with MBL you would certainly make anti-HIV antibodies if you had really been exposed to the virus. CLL is a particular disease much given to immunodeficiency and the same is not true for marginal zone lymphoma, where increased antibody production is more likely, especially in the early phase. Nobody is really sure why CLL is so different, but it is something to do with the CLL cells suborning the role of antigen presenting cell from CD14+ dendritic cells.<br /><br />My advice would be to put this out of your mind and be reassurred. I know that it is difficult. Your final alternative would be to test for HIV again with an RT-PCR test.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-15198104136839234612011-07-14T20:10:07.277+01:002011-07-14T20:10:07.277+01:00Terry
I have asked you before the same question bu...Terry<br />I have asked you before the same question but really, out of sympathy, I beg for your answer again. I trust you so much. I am obsessive about one issue: I have MBL (CD5neg; CD20+; CD11c) - stable, assymptomatic, normal levels of immunneglobulins, no cytopenias, total lymphocytes count even decreased over these last 3 years since diagnsosis. My questions:<br />1)I had an occupational accident with a HIV positive person (I work in a hospital here in my country)...it was not that serious...basically his saliva into my eyes...anyway, I have been tested several times up to 9 months after the accident. I took a RNA PCR along with a p24 assay after 35 days from the accident. ALL negative! After that I have been tested by using Antibododies (only) Assays up to 9 months after the accident. Wouldn't I be able to produce antibodies having MBL? I am mentally sick since I started reading about immunodeficiencies related to CLL or other Lymphomas. <br />2)In your opinion, ALL indolent B cell lymphomas show significant demage of the immune system? I am a married man and I have to trust in my sero status regarding viruses. <br />3) Once you told me that problems in the "marginal zone" should not be a problem regarding antibody response. You told me it was a CLL problem. Why is it like that?<br />I am so sorry and ashamed for asking you that, but if I ask it to an infectious disease physician he/she would not know what MBL is so someone with your expertise should help me a lot more.<br />Stay well! God bless you!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-88118690557260158202011-07-14T19:31:04.793+01:002011-07-14T19:31:04.793+01:00This reference was omitted from the final article ...This reference was omitted from the final article but I think it was Nieto WG, Almeida J, Romero A, et al. Increased frequency (12%) of circulating CLL-like B-cell clones in healthy individuals using a high-sensitive multicolor flow cytometry approach. Prepublished online May 6, 2009;doi:10.1182/blood-2009-01-197368 Accessed July 3rd 2009. <br /><br />or possibly this one <br /><br />Nieto WG, Teodosio C, López A, Rodríguez-Caballero A, Romero A, Bárcena P, Gutierrez ML, Langerak AW, Fernandez-Navarro P, Orfao A, Almeida J; Cytometry B Clin Cytom. 2010;78 Suppl 1:S24-34.<br />Non-CLL-like monoclonal B-cell lymphocytosis in the general population: prevalence and phenotypic/genetic characteristics.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-49126843336616726342011-07-14T03:21:43.985+01:002011-07-14T03:21:43.985+01:00Terry
Would you please write me reference #13? Tha...Terry<br />Would you please write me reference #13? Thank you!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-14828308012343115802011-07-12T16:59:05.506+01:002011-07-12T16:59:05.506+01:00Hi Terry
Would you please right me the reference n...Hi Terry<br />Would you please right me the reference number 13?<br />Thank you!Anonymousnoreply@blogger.com