tag:blogger.com,1999:blog-19490962.post601473710702770351..comments2023-12-10T10:06:41.979+00:00Comments on mutations of mortality: Why should I get my prognostic markers done?Terry Hamblinhttp://www.blogger.com/profile/06346629921055055879noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-19490962.post-90102215203086044472008-07-15T10:49:00.000+01:002008-07-15T10:49:00.000+01:00Trisomy 12 adds nothing to being unmutated. It is ...Trisomy 12 adds nothing to being unmutated. It is a rather different disease from the point of view of the pathologist, but it makes no difference to the patientTerry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-35335841887281768642008-07-15T03:19:00.000+01:002008-07-15T03:19:00.000+01:00Dr. Hamblin, What can you tell me about having an...Dr. Hamblin,<BR/> What can you tell me about having an extra 12 chromosome? With all the discussion of deletions of other chromosomes I haven't come across much about this extra 12. If I am unmutated, what does this mean for me exactly? Thanks!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-42437574550273526932007-05-10T07:54:00.000+01:002007-05-10T07:54:00.000+01:00Sorry I must have misunderstood your post.50 out o...Sorry I must have misunderstood your post.<BR/><BR/>50 out of 150 had poor prognostic indicators and died.<BR/><BR/>100 with good indicators have not died.<BR/><BR/>I assumed that 100 was two thirds of the sample ie 66%.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-18728123854445315992007-05-09T19:30:00.000+01:002007-05-09T19:30:00.000+01:00Because the unmutated subset is dying more rapidly...Because the unmutated subset is dying more rapidly than the mutated subset.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-72081726113392386592007-05-09T14:56:00.000+01:002007-05-09T14:56:00.000+01:00"It's the difference between 69% and 53% and the g..."It's the difference between 69% and 53% and the gap is widening every year."<BR/><BR/>Why is the gap widening, exactly?justmehttps://www.blogger.com/profile/00432622549940230450noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-21082790868166057292007-05-09T12:47:00.000+01:002007-05-09T12:47:00.000+01:00I am one of those who relish knowing all the numbe...I am one of those who relish knowing all the numbers.<BR/><BR/>About your study of 150 Binet A patients with absolute lymphocyte counts less than 30....is this at initial diagnosis only? I think one of your earlier posts said so. If this ALC less than 30 criterion applied throughout the course of the disease, then it could be a self-fulfilling prophecy.<BR/><BR/>Thanks.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-17307552734960118992007-05-09T09:51:00.000+01:002007-05-09T09:51:00.000+01:00Steve,Yes, that is pretty well what the figures sa...Steve,<BR/><BR/>Yes, that is pretty well what the figures say, though admittedly the data have not been tested by being published in a peer-reviewed publication. We are expanding the numbers and doing all the prognostic markers to be sure, but the data so far say that if you have a Hb greater than 12, a platelet count greater than 100, a CD38 less than 30%, no lymph nodes, spleen or liver to feel then the actuarial survival in our series (censoring for non-CLL deaths) is 100%, and the treatment-free survival is 89%.<BR/><BR/>CLL-related deaths are deaths from infection, treatment, transformation, marrow failure. Cancer deaths were not regarded as CLL-related unless they were from melanoma, lymphoma or leukemia. In this population the common cancers are common in both normals and patients with CLL and the sample is too small to sort out noise from signal. <BR/><BR/>However, this is not 60% of CLLs. In our series it comprises about a quarter of patients. <BR/><BR/>One caveat is that although the longest survivor is out at more than 25 years, some patients have only been observed for 3 years. this is an actuarial curve and as time passes it might change.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-53101505385613564582007-05-09T09:19:00.000+01:002007-05-09T09:19:00.000+01:00Terry.Do I understand you correctly? If you have C...Terry.<BR/><BR/>Do I understand you correctly? <BR/><BR/>If you have CLL and your WBC never gets over 30k and you have good prognostic indicators you have a 100% chance of of survival, compared to an age and sex matched cohort at 20 years?<BR/><BR/>If this is true, and I am sure it is from your sample of patients, it means that 66% of CLL people should be told to forget about it.<BR/><BR/>Is the quality of life of these people affected? What constitutes "death by CLL"?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-70156885729129041642007-05-08T19:17:00.000+01:002007-05-08T19:17:00.000+01:00Yes, of course, thanks for the correction. Clumsy ...Yes, of course, thanks for the correction. Clumsy of me. It's the difference between 69% and 53% and the gap is widening every year.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-40904872714283670582007-05-08T18:19:00.000+01:002007-05-08T18:19:00.000+01:00Do you mean 16 percentage points? I assume that i...Do you mean 16 percentage points? I assume that is what you mean (i.e. the difference between 50% and 66% is 16 percentage points, not 16%). Percentages of percentages are meaningless.<BR/><BR/>Since a post in Wikipedia has explained it, I don't have to:<BR/><BR/>"Percentage points (PP) are the proper unit for the arithmetic difference of two percentages.<BR/><BR/>Consider the following hypothetical example: in 1980, 40 percent of the population smoked, and in 1990 only 30 percent smoked. We can thus say that from 1980 to 1990, the incidence of smoking decreased by 10 percentage points even though smoking has not decreased by 10 percent; since percentages indicate ratios—not differences."Anonymousnoreply@blogger.com