tag:blogger.com,1999:blog-19490962.post5928868156074543668..comments2023-12-10T10:06:41.979+00:00Comments on mutations of mortality: Immunodeficiency 6Terry Hamblinhttp://www.blogger.com/profile/06346629921055055879noreply@blogger.comBlogger14125tag:blogger.com,1999:blog-19490962.post-67300981633663199392008-06-09T13:49:00.000+01:002008-06-09T13:49:00.000+01:00There is no vaccine for hepatitis C.There is no vaccine for hepatitis C.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-40548830697481065532008-06-09T13:23:00.000+01:002008-06-09T13:23:00.000+01:00He should NOT get HEP c?He should NOT get HEP c?Sierrahttps://www.blogger.com/profile/05441016152053818722noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-18265306030213927912008-06-09T12:04:00.000+01:002008-06-09T12:04:00.000+01:00Have all the vaccines that are permissable.Have all the vaccines that are permissable.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-25820628917064005322008-06-09T12:00:00.000+01:002008-06-09T12:00:00.000+01:00My husband, diagnosed with stage 0 CLL 11/04 is tr...My husband, diagnosed with stage 0 CLL 11/04 is traveling to India in July. It was suggested that he get vaccinated for HEP a, b and c. What is the general concensus regarding that?Sierrahttps://www.blogger.com/profile/05441016152053818722noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-17266470245283673602008-05-30T19:02:00.000+01:002008-05-30T19:02:00.000+01:00Thanks for the link. It is clearly a mechanism wor...Thanks for the link. It is clearly a mechanism worth exploring.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-36850455482020442892008-05-30T18:18:00.000+01:002008-05-30T18:18:00.000+01:00I've read all of your sections about innunodeficie...I've read all of your sections about innunodeficiency and although I'm sure this comment would be better placed in one of the other ones, I'm placeing it here. The Journal of Experimental Medicine posted an article "Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo."<BR/>Volume 202, No. 6, 2005. This may be a link: www.jem.org/cgi/content/full/202/6/817<BR/>There is a summary article in the same edition titled "Blocking acid, boosting T cells". Do you believe this antimalarial drug could help CLLers respond better to some vaccines?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-82142660759387580732008-05-29T08:04:00.000+01:002008-05-29T08:04:00.000+01:00There is no scientific reason for it, but I am a g...There is no scientific reason for it, but I am a good example of a CLL patient who was suddenly very healthy. The flu, colds and other diseases would sweep through the office, and I would never, ever get any of it.<BR/><BR/>Now, almost 10 years into CLL, I am no longer 'protected'.<BR/><BR/>There is no reason why this should be, but I can attest that, at least in my case, I was remarkably healthy.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-84801145101989574052008-05-28T18:01:00.000+01:002008-05-28T18:01:00.000+01:00The imiquamod study ios not yet complete. There is...The imiquamod study ios not yet complete. There is no evidence that exercise can boost the immune system. You have to realise that the suppression of the immune system in CLL is a result of specific damage done by teh presence of the CLL cells It cannot be remedied by non-specific 'boosts'. The only thing I know that makes a difference is treatment with high dose rituximab.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-18368342890262816932008-05-28T17:54:00.000+01:002008-05-28T17:54:00.000+01:00Everybody with CLL has some degree of impairmant o...Everybody with CLL has some degree of impairmant of immunity. Even newly diagnosed patients tend to have some reduction of serum Ig, though as time passes it gets worse. I have seen normal Igs fall to very low in 3 years without treatment.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-862211667890762092008-05-28T06:08:00.000+01:002008-05-28T06:08:00.000+01:00I am wondering if any results are available on the...I am wondering if any results are available on the Imiquimod enhancement study? <BR/><BR/>Also, there are some indications that exercise can boost the immune system but I am not aware of studies showing this to be true for CLL patients. Do you have any information on this?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-78116583225138616772008-05-27T23:39:00.000+01:002008-05-27T23:39:00.000+01:00There is anecdotal evidence, from CLL websites, th...There is anecdotal evidence, from CLL websites, that some CLL patients have fewer infections than their peers when first diagnosed. <BR/><BR/>Have the figures you quote on reduced immunoglobulins typically been measured in patients with advanced disease and have any studies been made of levels when people first present with disease in its early stages.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-22236328681667133782008-05-27T23:06:00.000+01:002008-05-27T23:06:00.000+01:00Thanks for the comments. I suppose pneumovax 23 sh...Thanks for the comments. I suppose pneumovax 23 should be even though it doesn't work. IgA going down first was jus an old report. Any and every patern has been seen.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-14575775543408676622008-05-27T22:25:00.000+01:002008-05-27T22:25:00.000+01:00After your post on the Prevenar vaccine I persuade...After your post on the Prevenar vaccine I persuaded my GP to get my immunoglobulins measured as I thought they might give an indication as to whether there was any point in my having a vaccination. I expected all the levels to be depressed and I see you suggest that IgA is usually the first to drop. <BR/><BR/>IgG was mid normal range, IgM was within normal range but one SD below normal but IgA was ABOVE normal at 4.69 (0.8-4).<BR/><BR/>Is this another problem rearing its head or is it something one might expect in the early stages when one has a few too many B cells.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-754105263690712952008-05-27T22:21:00.000+01:002008-05-27T22:21:00.000+01:00Should pneumovax 23 be on the permissable list?Should pneumovax 23 be on the permissable list?Anonymousnoreply@blogger.com