tag:blogger.com,1999:blog-19490962.post5538153425082510246..comments2023-12-10T10:06:41.979+00:00Comments on mutations of mortality: Questions and answers on CD38Terry Hamblinhttp://www.blogger.com/profile/06346629921055055879noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-19490962.post-54481034663664169172011-10-21T09:47:48.178+01:002011-10-21T09:47:48.178+01:001% CD38 almost certainly indicates a good prognosi...1% CD38 almost certainly indicates a good prognosisTerry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-42225574114873923442011-10-21T00:17:28.894+01:002011-10-21T00:17:28.894+01:00If someone has 1% CD 38 cells, what does that indi...If someone has 1% CD 38 cells, what does that indicate with regard to clinical course?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-25267566399359507352011-10-20T11:02:40.165+01:002011-10-20T11:02:40.165+01:00CD38 does vary but not very much in most cases. I...CD38 does vary but not very much in most cases. I have not seen any results after treatment with PCI or CAl 101.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-38762604883577586122011-10-19T23:26:33.010+01:002011-10-19T23:26:33.010+01:00Overall it seems to me that the variability of CD3...Overall it seems to me that the variability of CD38 is self-defeating, making it a less than ideal clinical tool for use in the "real world", even though it seems to have substabtial research value...most likely as a "dynamic" marker of CLL cell activity vis-a-vis CLL cell interaction with other cells, proliferation, etc.<br /><br />I am curious, however, whether you are aware if anyone has tested the obvious conclusion...ie, do CD38 levels fall in patients who respond to BTK &/or PI3K inhibitors? Perhaps no one has bothered to check.<br /><br />Hope that you remain as vigorous as you seem to be at present,<br /><br />RickAnonymousnoreply@blogger.com