tag:blogger.com,1999:blog-19490962.post5227804516422697945..comments2023-12-10T10:06:41.979+00:00Comments on mutations of mortality: Gene therapy for CLLTerry Hamblinhttp://www.blogger.com/profile/06346629921055055879noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-19490962.post-91342646703109193932011-06-02T22:45:51.011+01:002011-06-02T22:45:51.011+01:00Lumiliximab was not a particularly good monoclonal...Lumiliximab was not a particularly good monoclonal and I didn't think it was worth commiting patients to that trial when I was practising. I was proved right.<br /><br />CAR technology just needs a target confined to CLL cells; it doesn't matter how the antibody performed.<br /><br />There are some pretty good results with other examples of CAR technology and I am impressed by the possibilities. The CD28 is there to activate the T cells and keep them proliferting.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-1158822581884128512011-06-02T21:56:16.649+01:002011-06-02T21:56:16.649+01:00Terry,
The CD23 mAb Lumiliximab was pretty unimpr...Terry,<br /><br />The CD23 mAb Lumiliximab was pretty unimpressive in clinical trials and I do not remember if a reason for its lack of more efficient cell lysis was ever given.<br /><br />CAR development appears more sophisticated than mAb technology but still uses CD23 as a target. Is efficacy with CAR wishful thinking or do you believe the problems in effective targeting of CD23 are accurately understood?<br /><br />Does the CD28 costimulatory factor affect the binding or killing mechanism of the CAR complex?<br /><br />Thanks,<br /><br />WWWWaynehttps://www.blogger.com/profile/12333087913528941756noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-65481592061896821282011-06-01T17:44:19.833+01:002011-06-01T17:44:19.833+01:00There are several of these gene therapy programs u...There are several of these gene therapy programs underway with CAR. I think that they could be rolled out within 5 years.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-57183712799950099152011-06-01T15:12:00.322+01:002011-06-01T15:12:00.322+01:00Off the cuff, how practical do you suppose it woul...Off the cuff, how practical do you suppose it would be to move such technology from mice to men and how long might the necessary work take to reach a level of clinical practicality, assuming that no unforseen major issues arise in such work?<br /><br />Thanks, RickAnonymousnoreply@blogger.com