tag:blogger.com,1999:blog-19490962.post502838824421751935..comments2023-12-10T10:06:41.979+00:00Comments on mutations of mortality: FCR and MDSTerry Hamblinhttp://www.blogger.com/profile/06346629921055055879noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-19490962.post-53990026668989606502010-11-29T03:42:40.101+00:002010-11-29T03:42:40.101+00:00FCR has been linked to both MDS and Richter's ...FCR has been linked to both MDS and Richter's transformation.<br /><br />With that, and the other options out there (Revlimid and rituximab, high-dose methylprednisolne with rituximab, chlorambucil, EGCG, and others), why would one even consider FCR if they have other options?<br /><br />FCR can't be a gold standard when it starts killing people by itself.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-85857800385827963902010-11-28T23:20:56.357+00:002010-11-28T23:20:56.357+00:00A new study published in Leukemia has looked at tr...A new study published in Leukemia has looked at treatment related MDS/AML in fludarabine combo therapies.<br /><br />5 of 82 patients with CLL developed t-MDS/AML.<br /><br />They state: "There was a trend toward prior cytotoxic therapy increasing the risk for t-MDS/AML (P=0.067). Fludarabine combination chemotherapy is associated with a moderate risk of t-MDS/AML particularly when combined with mitoxantrone." <br /><br /><br /><br />~chris<br /><br />Leukemia , (21 October 2010) | doi:10.1038/leu.2010.218CLL CANADAhttp://cllcanada.canoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-47868925032008605242010-11-24T18:10:17.413+00:002010-11-24T18:10:17.413+00:00No, they just happened to have two diseases at the...No, they just happened to have two diseases at the same time, both diagnosable from a bone marrow aspirate. Just a coincidence? or is there an underlying tendency to bone marrow malignancy.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-62771947479240568792010-11-24T15:49:30.019+00:002010-11-24T15:49:30.019+00:00I don't understand why patient were being sim...I don't understand why patient were being simultaneously dxed with CLL and MDS. What is the relationship? Was it misdiagnosis or does CLL turn into MDS?<br /><br />john listonAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-80820251517327322742010-11-23T15:58:34.631+00:002010-11-23T15:58:34.631+00:00Not certain, but I suspect so.Not certain, but I suspect so.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-30067128543750318622010-11-23T15:38:18.196+00:002010-11-23T15:38:18.196+00:00In this last group that you mentioned...those with...In this last group that you mentioned...those with post rituximab neutropenia...does splenic sequestration of neutrophils preclude their release in the circumstance of infection? In other words, is the neutropenia more cosmetic than worrisome in this group?Anonymousnoreply@blogger.com