tag:blogger.com,1999:blog-19490962.post2907194711788106793..comments2023-12-10T10:06:41.979+00:00Comments on mutations of mortality: Secondary leukemiaTerry Hamblinhttp://www.blogger.com/profile/06346629921055055879noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-19490962.post-38240275972857687492007-08-06T14:04:00.000+01:002007-08-06T14:04:00.000+01:00http://path.upmc.edu/cases/case378/dx.html gives a...http://path.upmc.edu/cases/case378/dx.html gives a description of desmoplastic melanoma beginning<BR/>"Desmoplastic melanoma is a term first used by Conley in 1971 to describe a variant of melanoma characterized by a dermal spindle cell population in a background of abundant collagen. Eight years later, Reed and Leonard used the term desmoplastic neurotropic melanoma to describe desmoplastic melanomas with nerve infiltration. Although desmoplastic melanoma may arise de novo, it is most commonly associated with other types of melanoma, mainly lentigo maligna. Like lentigo maligna, desmoplastic melanoma occurs in older individuals, most commonly in the sixth decade of life, and has a slight predilection for males (male-to-female ratio 1.75:1) (5). Lesions are most often located on sun-exposed skin of the head and neck but can also be located on the trunk or extremities."<BR/><BR/>Like other melanomas, UV light is a likely culprit and immunodeficincy may play a part.<BR/><BR/>It is likely that further immuosuppressive treatment will increase the likelihood of relapse and recurrence.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-89201780515183121482007-08-03T15:42:00.000+01:002007-08-03T15:42:00.000+01:00My wife had a desmoplastic malignant melanoma pop ...My wife had a desmoplastic malignant melanoma pop up within a few days of her being diagnosed with CLL. Is this type melanoma associated with CLL, sun abuse when younger, or something else? On dx her white count was already 40 so she had the CLL for a while. She has good progs de13q14, cd38-, mutated 4.1%, b2m 1.75, stage 1, but with a ZAP70 of 65-70%. She is worried that treatment when required will trigger another melanoma. Where can she find more info about DMM? We have not had much luck on the internet. Gentle treatment that doesn't hit the T cells too hard or hit it hard and get out (PCR of Fcr) - Any thoughts on that?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-19100893968131265602007-07-28T00:09:00.000+01:002007-07-28T00:09:00.000+01:00It seems to me that the importance of knowing ones...It seems to me that the importance of knowing ones deletions has assumed a more necessary requirement than ever before. Maybe it has always been so, but was not so readily available as it is today.<BR/><BR/>I remember when I was first diagnosed 97- 99 and had gained a little experience of CLL, the patient was more conscious of WBC counts, HGB, HCT, Platelet, and ANC. I know in those days deletions were not mentioned.<BR/><BR/>Perhaps you could comment on the need to know of ones deletions. I am sure it is something that the local Oncologist/Hematologist does not discuss too much, mine doesn’t.<BR/><BR/>I believe the rule is, that one should have a FISH done before a contemplated treatment change.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-81846463785123440322007-07-27T10:08:00.000+01:002007-07-27T10:08:00.000+01:00Is this a case of do it and you die. Don't do it ...Is this a case of do it and you die.<BR/><BR/> Don't do it and you die.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-6237088955791230032007-07-27T09:12:00.000+01:002007-07-27T09:12:00.000+01:00Is secondary cancer commoner after FCR? We will ha...Is secondary cancer commoner after FCR? We will have to wait and see. I have always considered it a possibility, but we will need long term follow-up to know one way or the other. I'm not jumping to conclusions.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-62553099589561979902007-07-27T09:09:00.000+01:002007-07-27T09:09:00.000+01:00Not in the sense that it is induced by DNA damagin...Not in the sense that it is induced by DNA damaging drugs. It is a feature of the immune deficiency of CLL, which can be made worse by treatment. Melanoma is similar to mouse tumors induced by UV light in that it is commonner in individuals whose immunity is suppressed.Terry Hamblinhttps://www.blogger.com/profile/06346629921055055879noreply@blogger.comtag:blogger.com,1999:blog-19490962.post-40108591043175206052007-07-27T07:26:00.000+01:002007-07-27T07:26:00.000+01:00So, do you think those who have taken FCR are at r...So, do you think those who have taken FCR are at risk for future cancers? FCR is quite common now.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-19490962.post-37052330584779928082007-07-27T03:17:00.000+01:002007-07-27T03:17:00.000+01:00Terry,would you consider Melanoma as a secondary c...Terry,<BR/>would you consider Melanoma as a secondary cancer to CLL? My husband had a dx of melanoma 1 year after treatment with FCR and 2 1/2 years after dx of CLL. I figured it was because of the T-cells not working properly. Maybe it is a "side" cancer of CLL.Anonymousnoreply@blogger.com